Posts by: Alice Melao

News

Despite the increasing number of treatments, children with juvenile idiopathic arthritis (JIA) still experience disease activity most of the time, real-world data from Sweden suggest. The findings highlight the need ... Read more

November 12, 2019November 12, 2019

Xeljanz Eases Symptoms and Disease Flares in Children with Polyarticular JIA, Phase 3 Trial Shows

News

Treatment with Xeljanz (tofacitinib) reduces disease flares, improves physical functioning, and significantly eases symptoms of polyarticular juvenile idiopathic arthritis (pJIA), results from a Phase 3 clinical trial show. The research, “Tofacitinib ... Read more

November 1, 2019November 1, 2019

IL1RN Gene Variants Do Not Affect Response to Kineret or Ilaris in Systemic JIA, German Study Suggests

News

Variants in the gene leading to the protein interleukin-1 receptor antagonist (or IL1RA) do not seem to affect the response of children with systemic juvenile idiopathic arthritis (sJIA) to the ... Read more

October 25, 2019October 25, 2019

Early Use of Infliximab Eases Inflammation and Affected Joints in Polyarticular JIA Patients, Study Reports

News

Early treatment with infliximab — sold under the brand name Remicade, among others — leads to lower inflammation and fewer joints showing active disease over 12 months in children and adolescents ... Read more

August 2, 2019August 2, 2019

Juvenile Idiopathic Arthritis Relatively Prevalent Among School-Aged Children in Brazil, Study Finds

News

Juvenile idiopathic arthritis is relatively prevalent among school-aged children in Brazil, affecting 196 children for every 100.000, a population-based study reveals. The study, “Prevalence of juvenile idiopathic arthritis in schoolchildren ... Read more

April 9, 2019April 9, 2019

New Enbrel Biosimilar YLB113 Is Now Available in Japan

News

Japanese patients with rheumatoid arthritis and juvenile arthritis can now be treated with a biosimilar therapy of Enbrel (etanercept). The Japanese Pharmaceuticals and Medical Devices Agency (PMDA) has approved the request of ... Read more

April 2, 2019April 2, 2019

Treatment Failure, Adverse Reactions in JIA Patients Potentially Linked to Antibodies Against Biologic Agents, Study Suggests

News

Approximately 17% of juvenile idiopathic arthritis (JIA) patients treated with biologic agents develop anti-drug antibodies (ADAbs) that can be associated with treatment failure and adverse events, a review study shows. ... Read more

March 8, 2019March 8, 2019

Spanish Survey Reveals Pediatricians’ Misconceptions About JIA

News

Approximately half of pediatricians and pediatric residents in Spain have wrong beliefs and misconceptions about the incidence and manifestation of juvenile idiopathic arthritis, a national survey showed. The findings were ... Read more

February 19, 2019February 19, 2019

Children with JA Plus Enthesitis Report Worse Pain, Quality of Life, Canadian Study Finds

News

Children with juvenile arthritis who also have enthesitis have worse quality of life, impaired function, and higher pain intensity according to self-reported outcomes, a large-scale study shows. The study, “Children ... Read more

January 29, 2019January 29, 2019

Twin Study Identifies NFIL3 Gene Mutation as Potential Driver of Juvenile Arthritis

News

By studying identical twin girls with juvenile arthritis, researchers have found that a single mutation in the NFIL3 gene may cause the disease. The study, “NFIL3 mutations alter immune homeostasis and ... Read more