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February 19, 2019February 19, 2019

Children with JA Plus Enthesitis Report Worse Pain, Quality of Life, Canadian Study Finds

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Children with juvenile arthritis who also have enthesitis have worse quality of life, impaired function, and higher pain intensity according to self-reported outcomes, a large-scale study shows. The study, “Children ... Read more

February 15, 2019February 15, 2019

More JIA Children Participate in School Sports Likely Because of Better Treatment Options, Study Shows

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More children and teenagers with juvenile idiopathic arthritis (JIA) have participated in school sports over the past 15 years, which is likely explained by better treatment options that improved their functional abilities, a ... Read more

February 12, 2019February 12, 2019

Study Examines Discontinuing Use of TNF-inhibitors Prior to Week 20 of Pregnancy in JA, RA Patients

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Pregnant women with well-controlled juvenile idiopathic arthritis and rheumatoid arthritis, and who discontinue treatment with TNF inhibitors prior to week 20 of pregnancy, do not experience worsening of their disease, ... Read more

February 8, 2019February 8, 2019

Time Between Dye Administration, MRI Can Affect Synovial Thickness

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How thick the synovial membrane (the layer of tissue that lines joints) appears in an MRI image after administration of a contrast-enhancing dye is time-dependent, a study shows. The variation ... Read more

February 5, 2019February 5, 2019

Interleukin-1 Inhibitors Show Excellent Retention Rates in sJIA Patients

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Sobi‘s Kineret (anakinra) and Novartis‘ Ilaris (canakinumab), two interleukin-1 inhibitors that have been approved by the U.S. Food and Drug Administration (FDA) for the treatment of systemic onset juvenile arthritis (sJIA), ... Read more

February 1, 2019February 1, 2019

JIA Patients with CAT Gene Mutation Less Likely to Respond to Anti-TNF-α Therapy

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Patients with juvenile idiopathic arthritis (JIA) who carry a mutation in the CAT gene are less likely to respond to anti-TNF-alpha therapy, a new study suggests. Having this mutation increases the risk of ... Read more

January 29, 2019January 29, 2019

Twin Study Identifies NFIL3 Gene Mutation as Potential Driver of Juvenile Arthritis

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By studying identical twin girls with juvenile arthritis, researchers have found that a single mutation in the NFIL3 gene may cause the disease. The study, “NFIL3 mutations alter immune homeostasis and ... Read more

January 25, 2019January 25, 2019

Neutrophil-Mediated Inflammation Persists Despite Long-term Inactive JIA, Study Shows

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Patients with either active or clinically inactive systemic juvenile idiopathic arthritis are characterized by persistent innate immune activation, new research reports. The study, “Neutrophils From Children With Systemic Juvenile Idiopathic Arthritis ... Read more

January 22, 2019January 22, 2019

Hand Grip Strength Could Be Tool to Assess JIA Activity in Children

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Hand grip strength could be a non-invasive tool to evaluate disease activity, disability and quality of life in children and adolescents with juvenile idiopathic arthritis, according to a study. The ... Read more