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January 28, 2020January 28, 2020

JIA Children Have Lower Levels of Enzymes that Suppress Gene Activity, Study Suggests

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Children with juvenile idiopathic arthritis (JIA), particularly boys, have significantly lower levels of DNA methyltransferases (DNMTs) — specific enzymes that suppress gene activity without changing their sequence — than healthy children, ... Read more

January 24, 2020January 24, 2020

Off-label Use of Xeljanz and Olumiant Effective Against Eye Inflammation in JIA, Case Study Shows

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Off-label use of Xeljanz and Olumiant effectively treated uveitis — a form of eye inflammation — and was well-tolerated by four patients with juvenile idiopathic arthritis (JIA) who had failed ... Read more

January 21, 2020January 21, 2020

Combined Testing of Inflammatory Biomarkers and Clinical Info Helps Predict Short-term JIA Activity, Study Finds

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Testing five blood biomarkers while taking into account clinical characteristics of children with newly diagnosed juvenile idiopathic arthritis (JIA) can help predict their disease activity in the short term, a ... Read more

January 17, 2020January 17, 2020

Long-term Use of Biologic Therapies for sJIA Are Safe, Study Finds

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Long-term use of biologic therapies in people with systemic-onset juvenile idiopathic arthritis (sJIA) is acceptably safe, with varying rates of infections and macrophage activation syndrome depending on choice of medication, ... Read more

January 14, 2020January 14, 2020

Local Steroid Injection Treats Tear Gland Inflammation Found in JIA Patient, Study Reports

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People with juvenile idiopathic arthritis (JIA) may develop dacryoadenitis, or inflammation of the tear-producing glands of the eye, a case report found. Dacryoadenitis can be effectively treated with a local ... Read more

January 10, 2020January 10, 2020

Orofacial Pain in JIA Patients Linked to Disease Activity, Stress, and Daily Limitations, Study Reports

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People with juvenile idiopathic arthritis (JIA) who experience orofacial pain — pain in the mouth, face, and jaw — have more stress, limitations on daily activities, disease activity, and systemic inflammation than ... Read more

January 7, 2020January 7, 2020

Early DMARD Treatment Improves Quality of Life for Children with Polyarticular JIA, Study Suggests

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Early aggressive treatment with biologic and synthetic disease-modifying anti-rheumatic drugs (DMARDs) improved the quality of life of children with polyarticular juvenile idiopathic arthritis (pJIA) in Finland, according to one-year data from ... Read more

January 3, 2020January 3, 2020

Rare Skin Condition Affecting 4 Children with JIA Detailed in Case Report

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The cases of four children call attention to an unusual association of juvenile idiopathic arthritis (JIA) with morphea, a rare skin condition that can appear years after JIA onset and ... Read more

December 20, 2019December 20, 2019

Adults with JIA Satisfied with Biologics But Often Fail to Adhere to Therapy, Study Finds

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Adults with juvenile idiopathic arthritis (JIA) treated with disease-modifying antirheumatic drugs (DMARDs) are more satisfied with biological medicines than with synthetic therapies such as methotrexate, a study based on patient ... Read more

December 17, 2019December 17, 2019

Slightly Higher Cancer Risk in JIA Not Linked to Use of Biological Therapies, Study Says

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Children and adolescents with juvenile idiopathic arthritis (JIA) have a slightly higher risk of developing lymphoma and multiple myeloma compared to the general population, a study says. However, this higher ... Read more